Yang Bo, Su Ke, Gao Jianfei, Rao Zhiguo
Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, Wuhan, China.
Asian Pac J Cancer Prev. 2012;13(3):1049-52. doi: 10.7314/apjcp.2012.13.3.1049.
The purpose of this study was to evaluate expression and prognostic value of matrix metalloproteinase-7 (MMP-7) in colorectal cancer (CRC) patients. CRC tissues and corresponding distal normal mucosa tissues of 118 CRC patients were assessed by immunohistochemistry. Correlations between MMP-7 expression, patients' clinic pathological features, and overall survival rate were analyzed. We found that positive expression of MMP- 7 in CRC tissues was significantly higher than that in distal normal mucosa (61.0% vs. 39.8%, p=0.001). Poor histological differentiation, advanced clinical stage and lymph node metastasis were significantly correlated with MMP-7 expression in CRC. The overall survival rate was significantly higher in the MMP-7 negative group than the positive group (Log-rank test=9.957, p=0.002). MMP-7 appeared as a significant independent prognostic factor through multivariate survival analysis. Collectively, we found MMP-7 expression to be correlated with progression and metastasis of CRC and thus could be used as a predictive marker of prognosis in CRC patients.
本研究旨在评估基质金属蛋白酶-7（MMP-7）在结直肠癌（CRC）患者中的表达及预后价值。采用免疫组织化学方法对118例CRC患者的癌组织及相应远端正常黏膜组织进行评估。分析MMP-7表达与患者临床病理特征及总生存率之间的相关性。我们发现，CRC组织中MMP-7的阳性表达显著高于远端正常黏膜（61.0%对39.8%，p = 0.001）。CRC中组织学分化差、临床分期晚和淋巴结转移与MMP-7表达显著相关。MMP-7阴性组的总生存率显著高于阳性组（对数秩检验=9.957，p = 0.002）。通过多因素生存分析，MMP-7是一个显著的独立预后因素。总体而言，我们发现MMP-7表达与CRC的进展和转移相关，因此可作为CRC患者预后的预测标志物。
