Hu Qinglin, Yan Chuanjing, Xu Chengfei, Yan Hai, Qing Lian, Pu Yanjun, He Zeyou, Li Xiaojun
Department of General Surgery, the First Affiliated Hospital of Chengdu Medical College, Baoguang Road 278#, Chengdu, 610500, Sichuan, China,
Tumour Biol. 2014 Apr;35(4):3569-74. doi: 10.1007/s13277-013-1471-y. Epub 2013 Dec 8.
Tumor recurrence and metastasis are pressing issues of patients with colorectal cancer who receive surgery. Matrilysin-2 (MMP-26) has been proved to play an important role during invasion and metastasis of some human solid tumor. We aimed to investigate the clinical significance and prognostic value of matrilysin-2 in human colorectal cancer. Colorectal cancer and adjacent normal samples from 201 patients were collected. Matrilysin-2 expression level was investigated by immunohistochemistry assay, and its association with overall survival of patients was analyzed by statistical analysis. Results showed that matrilysin-2 expression level significantly elevated in colorectal cancer compared with adjacent normal specimens. Matrilysin-2 expression was also found to be associated with cancer invasion, lymph node metastasis, distant metastasis, and TNM stage. In addition, survival analysis showed that elevated matrilysin-2 expression was associated with poor overall survival of patients. Cox's proportional hazards model indicated that matrilysin-2 was an independent prognostic marker for patients with colorectal cancer. The present study found that the expression of matrilysin-2 increased in colorectal cancer and was associated with tumor progression. It also provided the first evidence that matrilysin-2 expression was an independent prognostic factor for patients with colorectal cancer, which might be a high specific biomarker for colorectal cancer.
肿瘤复发和转移是接受手术治疗的结直肠癌患者面临的紧迫问题。基质溶素-2（MMP-26）已被证明在某些人类实体瘤的侵袭和转移过程中发挥重要作用。我们旨在研究基质溶素-2在人类结直肠癌中的临床意义和预后价值。收集了201例患者的结直肠癌及相邻正常样本。通过免疫组织化学分析研究基质溶素-2的表达水平，并通过统计分析分析其与患者总生存期的关系。结果显示，与相邻正常标本相比，结直肠癌中基质溶素-2的表达水平显著升高。还发现基质溶素-2的表达与癌症侵袭、淋巴结转移、远处转移和TNM分期有关。此外，生存分析表明，基质溶素-2表达升高与患者总生存期较差有关。Cox比例风险模型表明，基质溶素-2是结直肠癌患者的独立预后标志物。本研究发现，基质溶素-2在结直肠癌中的表达增加，且与肿瘤进展有关。它还首次提供了证据，表明基质溶素-2表达是结直肠癌患者的独立预后因素，这可能是结直肠癌的一个高度特异性生物标志物。
