Department of Dental Hygiene, College of Applied Sciences and Arts, Southern Illinois University, Carbondale, IL, USA.
Curr Pharm Des. 2012;18(34):5532-41. doi: 10.2174/138161212803307464.
The use of topically applied fluoride has been widely researched as a means to reduce the risk of dental caries in conjunction with other treatment modalities (mechanical oral hygiene, dietary control, antimicrobial intervention, pit and fissure sealants). There is overwhelming evidence that reports not only the significance and importance of the use of fluoride as a caries-preventive agent, but also how safe fluoride application is when used appropriately, particularly in higher risk individuals and populations. This paper reviews the caries-protective benefits of topical fluoride application in children and adolescents, with an emphasis on the clinical efficacy and safety of the vehicles by which fluoride is topically delivered. Fluoride toothpaste represents today the most cost-effective fluoride-delivery system in the oral cavity and its use should be the centerpiece in all caries-preventive strategies. On the other hand, mouthrinses, gels and varnishes currently represent adjuncts to toothpaste use and should be targeted towards individuals and groups at high risk of caries.
局部用氟化物的使用已被广泛研究，作为与其他治疗方法（机械口腔卫生、饮食控制、抗菌干预、窝沟封闭剂）相结合减少龋齿风险的手段。有压倒性的证据表明，报告不仅说明了氟化物作为防龋剂的重要性和意义，还说明了氟化物的应用是多么安全，特别是在高风险的个体和人群中。本文综述了局部应用氟化物在儿童和青少年中的防龋作用，重点介绍了氟化物局部应用的载体的临床疗效和安全性。氟化物牙膏是目前口腔中最具成本效益的氟化物输送系统，其使用应成为所有防龋策略的核心。另一方面，漱口水、凝胶和涂料目前是牙膏使用的辅助手段，应针对龋齿高风险的个体和群体。
