Nugteren-Huying W M, van der Schroeff J G, Hermans J, Suurmond D
Academisch Ziekenhuis, afd. Dermatologie, Leiden.
Ned Tijdschr Geneeskd. 1990 Dec 8;134(49):2387-91.
Thirty-nine patients with psoriasis (12 females, 27 males) entered a randomised, double-blind, placebo-controlled study on the efficacy of fumaric acid therapy in an outpatient setting. During 16 weeks the patients were treated with tablets containing a combination of dimethylfumarate and different salts of monoethylfumarate, with octylhydrogen fumarate or with placebo tablets. All patients were treated with identical indifferent topical therapy and followed an elimination diet (avoidance of spices, wine and nuts). Thirty-four patients completed the study. Five patients dropped out because of side effects or aggravation of the skin lesions. The patients treated with the combination of monoethyl- and dimethylfumarate showed a significantly better therapeutic response compared with those who were treated with placebo or octylhydrogen fumarate. Side effects of the fumarate containing tablets were flushing, diarrhoea, a reversible elevation of transaminases, lymphocytopenia and eosinophilia. One patient developed a disturbance of the kidney function which normalised after discontinuation of the therapy.
39例银屑病患者（12例女性，27例男性）进入一项关于富马酸疗法在门诊环境中疗效的随机、双盲、安慰剂对照研究。在16周内，患者接受含有富马酸二甲酯和富马酸单乙酯不同盐类的组合片剂、富马酸氢辛酯片剂或安慰剂片剂治疗。所有患者均接受相同的无关局部治疗，并遵循排除饮食（避免食用香料、葡萄酒和坚果）。34例患者完成了研究。5例患者因副作用或皮肤病变加重而退出。与接受安慰剂或富马酸氢辛酯治疗的患者相比，接受富马酸单乙酯和富马酸二甲酯组合治疗的患者显示出明显更好的治疗反应。含富马酸盐片剂的副作用包括潮红、腹泻、转氨酶可逆性升高、淋巴细胞减少和嗜酸性粒细胞增多。1例患者出现肾功能障碍，在停止治疗后恢复正常。
