Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, The Netherlands.
Brain Lang. 2013 May;125(2):223-30. doi: 10.1016/j.bandl.2012.04.016. Epub 2012 May 23.
Magnetoencephalography (MEG) has shown pseudohomophone priming effects at Broca's area (specifically pars opercularis of left inferior frontal gyrus and precentral gyrus; LIFGpo/PCG) within ∼100ms of viewing a word. This is consistent with Broca's area involvement in fast phonological access during visual word recognition. Here we used online transcranial magnetic stimulation (TMS) to investigate whether LIFGpo/PCG is necessary for (not just correlated with) visual word recognition by ∼100ms. Pulses were delivered to individually fMRI-defined LIFGpo/PCG in Dutch speakers 75-500ms after stimulus onset during reading and picture naming. Reading and picture naming reactions times were significantly slower following pulses at 225-300ms. Contrary to predictions, there was no disruption to reading for pulses before 225ms. This does not provide evidence in favour of a functional role for LIFGpo/PCG in reading before 225ms in this case, but does extend previous findings in picture stimuli to written Dutch words.
脑磁图（MEG）在观察单词后约 100ms 时，在布罗卡区（具体为左侧下额回和中央前回的前回；LIFGpo/PCG）显示出伪同音字启动效应。这与布罗卡区在视觉单词识别中快速语音访问的参与一致。在这里，我们使用在线经颅磁刺激（TMS）来研究 LIFGpo/PCG 是否对视觉单词识别是必需的（而不仅仅是相关的），时间约为 100ms。在阅读和图片命名期间，在刺激开始后 75-500ms 时，将脉冲分别传递给荷兰语使用者的 fMRI 定义的 LIFGpo/PCG。在 225-300ms 之后，脉冲后阅读和图片命名的反应时间明显变慢。与预测相反，在 225ms 之前的脉冲对阅读没有干扰。这并没有提供证据支持 LIFGpo/PCG 在这种情况下在 225ms 之前在阅读中具有功能作用，但将先前在图片刺激中的发现扩展到了荷兰语书面单词。
