Department of Pathophysiology and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, N12 W6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan.
Curr Pharm Des. 2012;18(31):4827-38. doi: 10.2174/138161212803216933.
Rikkunshito is a kampo herbal medicine which is widely used in Japan for the treatment of the upper gastrointestinal symptoms of patients with functional dyspepsia (FD), gastroesophageal reflux disease (GERD), dyspeptic symptoms of postgastrointestinal surgery patients, and chemotherapy-induced dyspepsia in cancer patients. Recently, very unique characteristics of rikkunshito have been unveiled; oral administration of rikkunshito potentiates orexigenic action of ghrelin through several different mechanisms. In addition, several lines of evidence obtained from both animal and human studies indicate that rikkunshito can be an attractive and promising therapeutic option for the anorectic conditions including cisplatin-induced dyspepsia, anorexia of aging, stress-induced hypophagia, cancer cachexia-anorexia syndrome. In this review, we will highlight what is known about the orexigenic effect of rikkunshito with a special focus on an interaction with ghrelin signaling system.
和胃汤是一种汉方药，在日本被广泛用于治疗功能性消化不良（FD）、胃食管反流病（GERD）、胃肠道手术后消化不良患者、癌症患者化疗引起的消化不良等上胃肠道症状。最近，和胃汤的一些非常独特的特性被揭示出来；通过几种不同的机制，口服和胃汤可以增强胃饥饿素的食欲作用。此外，来自动物和人体研究的几条证据表明，和胃汤可能是一种有吸引力和有前途的治疗选择，可用于治疗包括顺铂引起的消化不良、衰老性厌食、应激引起的食欲减退、癌症恶病质-厌食综合征在内的厌食症。在这篇综述中，我们将重点介绍和胃汤的食欲促进作用，特别是其与胃饥饿素信号系统的相互作用。
