Takeda Hiroshi, Muto Shuichi, Nakagawa Koji, Ohnishi Shunsuke, Sadakane Chiharu, Saegusa Yayoi, Nahata Miwa, Hattori Tomohisa, Asaka Masahiro
Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, Sapporo, Hokkaido, Japan.
Methods Enzymol. 2012;514:333-51. doi: 10.1016/B978-0-12-381272-8.00021-0.
Rikkunshito is a kampo herbal medicine which is widely used in Japan for the treatment of the upper gastrointestinal symptoms of patients with functional dyspepsia, gastroesophageal reflux disease, dyspeptic symptoms of postgastrointestinal surgery patients, and chemotherapy-induced dyspepsia in cancer patients. Recently, very unique characteristics of rikkunshito have been unveiled; oral administration of rikkunshito potentiates orexigenic action of ghrelin through several different mechanisms. In addition, several lines of evidence obtained from both animal and human studies indicate that rikkunshito can be an attractive and promising therapeutic option for the anorectic conditions including cisplatin-induced dyspepsia, anorexia of aging, stress-induced hypophagia, and cancer cachexia-anorexia syndrome. In this chapter, we highlight the orexigenic effect of rikkunshito with a special focus on its interaction with ghrelin signaling system.
理气和中汤是一种汉方草药，在日本被广泛用于治疗功能性消化不良患者的上消化道症状、胃食管反流病、胃肠道手术后患者的消化不良症状以及癌症患者化疗引起的消化不良。最近，理气和中汤的非常独特的特性已被揭示；口服理气和中汤通过几种不同机制增强胃饥饿素的促食欲作用。此外，从动物和人体研究中获得的几条证据表明，理气和中汤对于包括顺铂引起的消化不良、衰老性厌食、应激性摄食减少和癌症恶病质 - 厌食综合征在内的食欲缺乏状况可能是一种有吸引力且有前景的治疗选择。在本章中，我们重点介绍理气和中汤的促食欲作用，特别关注其与胃饥饿素信号系统的相互作用。
