Department of Urology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2012 Jun;28(6):327-30. doi: 10.1016/j.kjms.2011.10.007. Epub 2012 Apr 3.
In order to determine the prognostic impact of lymphovascular invasion (LVI) in patients after radical prostatectomy, the retrospective data from our institution has been analyzed. From 1998 to 2010, 117 patients underwent radical prostatectomy. A total of 87 patients were included in this retrospective study. The relationship between LVI and advanced prostate cancer characteristics was evaluated by χ(2) test. The Kaplan-Meier method and meta-analysis were used to describe the impact of LVI invasion upon early biochemical failure after radical prostatectomy. LVI was observed in patients with clinically or pathologically aggressive prostate cancer including patients of higher preoperative risk group, higher preoperative PSA, advanced Gleason grade, and pathological T3 disease. LVI is also associated with early biochemical failure rate both in our report and in the literature. Therefore, LVI is a pathological feature which indicates prognosis correlates with aggressive prostate cancer behavior and results in early biochemical failure after radical prostatectomy.
为了确定根治性前列腺切除术后淋巴血管侵犯（LVI）对患者预后的影响，我们对本院的回顾性数据进行了分析。1998 年至 2010 年间，有 117 例患者接受了根治性前列腺切除术。共有 87 例患者纳入本回顾性研究。采用卡方检验评估 LVI 与晚期前列腺癌特征之间的关系。采用 Kaplan-Meier 法和荟萃分析描述 LVI 侵犯对根治性前列腺切除术后早期生化失败的影响。在临床上或病理上具有侵袭性的前列腺癌患者中观察到 LVI，包括术前风险较高的患者、术前 PSA 较高、高级别 Gleason 评分和病理 T3 疾病的患者。LVI 与本报告和文献中的早期生化失败率也相关。因此，LVI 是一种病理特征，表明与侵袭性前列腺癌行为相关，导致根治性前列腺切除术后早期生化失败。
