Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2012 Jun;28(6):341-4. doi: 10.1016/j.kjms.2011.11.017. Epub 2012 Apr 4.
Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant inherited cancer syndrome that expresses nonendocrine and endocrine tumors. Here, we describe a 42-year-old man with an initial presentation of low back pain and hypertension. Clinical assessments revealed pheochromocytoma, medullary thyroid carcinoma with bone metastasis, and parathyroid hyperplasia. MEN 2A was diagnosed, and a family history of pheochromocytoma was traced. Surgical resection of the pheochromocytoma of the adrenal gland resulted in a cure of the patient's hypertension. He received systemic chemotherapy with the "MAID" regimen (mesna, doxorubicin, ifosfamide, and dacarbazine) over three cycles of 3 weeks each, and showed a partial response.
多发性内分泌腺瘤病 2A 型（MEN 2A）是一种常染色体显性遗传的癌症综合征，表现为非内分泌和内分泌肿瘤。在这里，我们描述了一位 42 岁的男性，最初表现为腰痛和高血压。临床评估显示嗜铬细胞瘤、伴有骨转移的甲状腺髓样癌和甲状旁腺增生。诊断为 MEN 2A，并追溯到家族性嗜铬细胞瘤病史。肾上腺嗜铬细胞瘤的手术切除治愈了患者的高血压。他接受了三个周期的 3 周“MAID”方案（美司钠、阿霉素、异环磷酰胺和达卡巴嗪）全身化疗，显示部分缓解。
