感受挤压：活细胞挤压限制上皮细胞的密度。
Feeling the squeeze: live-cell extrusion limits cell density in epithelia.
机构信息
Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario M5S 3G9, Canada.
出版信息
Cell. 2012 May 25;149(5):965-7. doi: 10.1016/j.cell.2012.05.006.
Abstract
Tissues develop in confined volumes that can impose mechanical constraints on their growth, but it is unclear how cells respond to these limits to regulate tissue size and shape. Two papers show that overcrowding and cell deformation lead to the shedding of live cells to maintain homeostasis in epithelial cell sheets.
摘要
组织在有限的体积中发育，这可能对其生长施加机械约束，但细胞如何响应这些限制来调节组织大小和形状尚不清楚。两篇论文表明，细胞拥挤和变形会导致活细胞脱落，以维持上皮细胞层的体内平衡。
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