Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.
Clin Nutr. 2012 Dec;31(6):1018-21. doi: 10.1016/j.clnu.2012.04.016. Epub 2012 May 24.
BACKGROUND & AIMS: Although decreased levels of circulating TRAIL have been associated to cardiovascular risk and overall mortality, the mechanisms controlling TRAIL levels in physiopathological conditions are currently unknown. The aim of the present study was to investigate whether changes in the energy intake and insulin sensitivity may influence circulating TRAIL, and to analyze potential relationships between circulating TRAIL and changes in fat mass in healthy subjects receiving hypocaloric or hypercaloric diets.
Three distinct groups of participants were studied, at the end of a 14-day (n = 9), 35-day (n = 30) or 60-day (n = 16) period of experimental bed rest to induce insulin resistance and during controlled ambulation, after receiving eucaloric, hypocaloric or hypercaloric diets.
After bed rest conditions, energy restriction significantly decreased circulating TRAIL, while overfeeding significantly increased TRAIL levels with respect to eucaloric control subjects. Moreover, a positive correlation was found between levels of circulating TRAIL and energy intake as well as between circulating TRAIL and energy balance, as determined by changes in fat mass in these subjects.
Circulating levels of TRAIL exhibit a clear-cut positive correlation with the energy intake and balance in healthy subjects during experimental physical inactivity.
虽然循环 TRAIL 水平的降低与心血管风险和总体死亡率有关，但目前尚不清楚控制生理病理条件下 TRAIL 水平的机制。本研究旨在探讨能量摄入和胰岛素敏感性的变化是否会影响循环 TRAIL，并分析在接受低热量或高热量饮食的健康受试者中，循环 TRAIL 与体脂变化之间的潜在关系。
在为期 14 天（n=9）、35 天（n=30）或 60 天（n=16）的实验性卧床休息以诱导胰岛素抵抗后，以及在接受热量、低热量或高热量饮食后的控制活动期间，研究了三组不同的参与者。
卧床休息条件下，能量限制显著降低了循环 TRAIL，而过量喂养与热量摄入正常的对照组相比显著增加了 TRAIL 水平。此外，在这些受试者中，还发现循环 TRAIL 水平与能量摄入以及循环 TRAIL 与能量平衡之间存在正相关关系，能量平衡通过体脂变化来确定。
在实验性体力不活动期间，健康受试者的循环 TRAIL 水平与能量摄入和平衡呈明显正相关。
