Department of Diabetes and Endocrinology, Beaumont Hospital, Dublin, Ireland Centre for Preventive Medicine, School of Health and Human Performance, Dublin City University, Dublin, Ireland.
Eur J Clin Invest. 2012 Nov;42(11):1173-9. doi: 10.1111/j.1365-2362.2012.02703.x. Epub 2012 Jul 17.
Biomarkers of cardiovascular (CV) risk are tests that predict a patient's risk of future CV events. Recently, two proteins involved in vascular calcification; serum levels of osteoprotegerin (OPG) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) have emerged as potentially useful biomarkers. OPG levels are positively correlated with CV risk, whereas TRAIL levels show a negative correlation. Exercise training is known to reduce risk factors for CV disease by improving metabolism, vascular biology and blood flow. This study examined the effects of a 6-month exercise training programme on levels of OPG and TRAIL. Pulse wave velocity (PWV) and high-sensitivity C-reactive protein (hsCRP) were measured for comparative purposes.
Overweight and obese patients undertook a 6-month exercise programme. Patients participated in 4 h of primarily aerobic exercise per week of which 2 h were supervised. At the beginning and end of the programme, anthropometric measurements, PWV and serum levels of OPG, TRAIL and hsCRP were measured.
A total of 21 patients (17 men) aged 55.2 ± 10 years completed the programme. Mean body mass index decreased from 34.1 ± 5.8 to 32.6 ± 5.4 kg/m(2) (P<0.05), while waist circumference decreased from 111.8 ± 12.4 to 109.6 ± 12.8 cm (P<0.05). PWV decreased from 9.2 to 8.5 m/s (P<0.02). OPG, TRAIL and hsCRP levels did not change significantly.
Exercise training reduced PWV but not OPG, TRAIL or hsCRP in this population. These data suggest that while an intervention of this nature improves vascular tone, it does not exert significant effects on serum biomarkers related to atherosclerotic inflammation and calcification.
心血管（CV）风险生物标志物是预测患者未来 CV 事件风险的检测。最近，两种参与血管钙化的蛋白；骨保护素（OPG）和肿瘤坏死因子相关凋亡诱导配体（TRAIL）的血清水平已成为潜在有用的生物标志物。OPG 水平与 CV 风险呈正相关，而 TRAIL 水平呈负相关。运动训练通过改善新陈代谢、血管生物学和血流来降低 CV 疾病的危险因素。本研究检测了 6 个月运动训练计划对 OPG 和 TRAIL 水平的影响。为了比较，还测量了脉搏波速度（PWV）和高敏 C 反应蛋白（hsCRP）。
超重和肥胖患者进行了 6 个月的运动计划。患者每周参加 4 小时的主要有氧运动，其中 2 小时由监督。在计划开始和结束时，测量了人体测量学指标、PWV 以及 OPG、TRAIL 和 hsCRP 的血清水平。
共有 21 名（17 名男性）年龄为 55.2 ± 10 岁的患者完成了该计划。平均体重指数从 34.1 ± 5.8 降至 32.6 ± 5.4 kg/m²（P<0.05），腰围从 111.8 ± 12.4 降至 109.6 ± 12.8 cm（P<0.05）。PWV 从 9.2 降至 8.5 m/s（P<0.02）。OPG、TRAIL 和 hsCRP 水平无明显变化。
在该人群中，运动训练降低了 PWV，但没有降低 OPG、TRAIL 或 hsCRP。这些数据表明，虽然这种性质的干预改善了血管张力，但它对与动脉粥样硬化炎症和钙化相关的血清生物标志物没有显著影响。
