Department of Chemistry, Faculty of Science, Okayama University of Science, Ridaicho, Kita-Ku, Okayama 700-0005, Japan.
Int J Biol Macromol. 2012 Oct;51(3):215-20. doi: 10.1016/j.ijbiomac.2012.05.007. Epub 2012 May 23.
Psoralen immobilized polyvinyl alcohol (PVA-P) was synthesized from chloromethylmethoxypsoralen and polyvinyl alcohol. The psoralen part of PVA-P intercalated into the double-stranded DNA and formed covalent bonding between the psoralen and nucleic acid base after 365 nm UV irradiation. As a result, DNA and PVA-P produced a water-insoluble conjugate. This DNA-PVA-P conjugate maintained the double-stranded structure of DNA and possessed the DNA's property, such as intercalation. Therefore, the DNA-PVA-P conjugate selectively accumulated the planar-structure containing chemical compounds, such as biphenyl and dibenzofuran, from an aqueous multi-component solution. These DNA-PVA-P conjugates may have the potential to be utilized as a separation material for the selective removal of harmful compounds.
香豆素固载聚乙烯醇（PVA-P）是由氯甲基甲氧基香豆素和聚乙烯醇合成的。PVA-P 中的香豆素部分插入双链 DNA 中，在 365nm 的紫外光照射下，香豆素和核酸碱基之间形成共价键。结果，DNA 和 PVA-P 产生了不溶于水的共轭物。这种 DNA-PVA-P 共轭物保持了 DNA 的双链结构，并具有 DNA 的特性，如嵌入。因此，DNA-PVA-P 共轭物从水多组分溶液中选择性地聚集含有平面结构的化合物，如联苯和二苯并呋喃。这些 DNA-PVA-P 共轭物可能有潜力被用作选择性去除有害化合物的分离材料。
