Krysiak Robert, Okopień Bogusław
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
Neuro Endocrinol Lett. 2012;33(3):301-3.
Both adult-onset growth hormone deficiency and autoimmune polyglandular syndrome are more frequent clinical entities than previously thought. In light of research carried out in recent years, it seems that growth hormone deficiency may be associated with proinflammatory state. This study describes a unique case of adult-onset growth hormone deficiency secondary to a traumatic brain injury in a young man, which was followed by the development of autoimmune polyglandular syndrome type 3. We discuss diagnostic and treatment dilemmas associated with discovering and management of both disorders in this patient. We conclude that in predisposed individuals growth hormone deficiency may lead to the development of autoimmune disorders of endocrine glands and/or exacerbate their clinical course.
成人起病型生长激素缺乏症和自身免疫性多腺体综合征都是比以前认为的更为常见的临床病症。鉴于近年来开展的研究，生长激素缺乏症似乎可能与促炎状态有关。本研究描述了一名年轻男子因创伤性脑损伤继发成人起病型生长激素缺乏症的独特病例，随后发展为3型自身免疫性多腺体综合征。我们讨论了与该患者这两种病症的发现和管理相关的诊断和治疗困境。我们得出结论，在易感个体中，生长激素缺乏症可能导致内分泌腺自身免疫性疾病的发生和/或加剧其临床病程。
