脑啡肽的作用不会被“激肽释放酶 - II”抑制剂卡托普利所改变。

The actions of enkephalins are not modified by the "kininase-II" inhibitor captopril.

作者信息

Buckett W R

出版信息

Eur J Pharmacol. 1979 Aug 1;57(2-3):267-71. doi: 10.1016/0014-2999(79)90377-7.

Abstract

The "kininase-II" (EC 3.4.15.1) inhibitor captopril in concentrations up to 10(-4) M did not affect the actions of enkephalins on the isolated electrically stimulated guinea-pig ileum. Captopril (100 mg/kg i.p.) in mice did not influence stimulation-produced analgesia and did not show analgesic properties. It is concluded that "kininase-II" is not involved in enkephalin catabolism, since the pharmacological actions of enkephalins were not enhanced after inhibition of the enzyme by captopril.

摘要

“激肽酶II”（EC 3.4.15.1）抑制剂卡托普利在浓度高达10⁻⁴ M时，并不影响脑啡肽对离体电刺激豚鼠回肠的作用。给小鼠腹腔注射卡托普利（100毫克/千克）并不影响刺激产生的镇痛作用，且未表现出镇痛特性。结论是，“激肽酶II”不参与脑啡肽的分解代谢，因为在卡托普利抑制该酶后，脑啡肽的药理作用并未增强。