脑啡肽对前列腺素E1引起的豚鼠回肠收缩的抑制作用。
Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1.
作者信息
Jaques R
出版信息
Agents Actions. 1977 Sep;7(3):317-9. doi: 10.1007/BF01969562.
PMID:596315
Abstract
Methionine-enkephalin and leucine-enkephalin (m-enk and 1-enk) as well as D-Ala2-methionine-enkephalin amide have been shown to antagonize contractions of the isolated guinea-pig intestine elicited by PGE1, the last mentioned being the most potent of the three. The inhibitory effect of these pentapeptides is abolished by naloxone.
摘要
甲硫氨酸脑啡肽和亮氨酸脑啡肽（甲硫脑啡肽和亮脑啡肽）以及D-丙氨酸2-甲硫氨酸脑啡肽酰胺已被证明可拮抗前列腺素E1引起的离体豚鼠肠道收缩，上述最后一种是三者中最有效的。这些五肽的抑制作用可被纳洛酮消除。
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