McCue J P
Exp Hematol. 1979 Aug;7(7):361-8.
The higher superoxide dismutase (SOD) levels found in human blood cells when Nitro Blue Tetrazolium (NBT) rather than Cytochrome C was used as the colorimetric detector of superoxide (O-2) was investigated. the NBT was found to react with oxygen radicals other than O-2, thus providing measurement of total oxygen radical scavenging ability. Also investigated was the biomodal distribution of SOD activity in lymphocytes and granulocytes from a randomly selected human populace. Human lymphocytes rapidly increased their SOD activity by two- to four-fold during respiratory viral distress. The response to certain infections was probably responsible for the bimodal distribution of SOD activity in the general populace. It was concluded that the chemical events that prepare lymphocytes and granulocytes for their role in defense against infections begin long before these cells are sequestered from circulation by the infections.
研究了在使用硝基蓝四唑（NBT）而非细胞色素C作为超氧阴离子（O-2）的比色检测器时，人体血细胞中发现的较高超氧化物歧化酶（SOD）水平。发现NBT与O-2以外的氧自由基反应，从而提供了对总氧自由基清除能力的测量。还研究了来自随机选择的人群的淋巴细胞和粒细胞中SOD活性的双峰分布。人类淋巴细胞在呼吸道病毒感染时，其SOD活性迅速增加两到四倍。对某些感染的反应可能是导致普通人群中SOD活性双峰分布的原因。得出的结论是，使淋巴细胞和粒细胞为其在抵抗感染中发挥作用做好准备的化学事件，早在这些细胞因感染而从循环中隔离之前就开始了。
