Malan Daniela, Fleischmann Bernd K
Institute of Physiology I, Life and Brain Center, University of Bonn, Sigmund-Freud-Strasse 25, 53105, Bonn, Germany.
Pediatr Cardiol. 2012 Aug;33(6):907-15. doi: 10.1007/s00246-012-0360-2. Epub 2012 May 26.
Voltage-dependent L-type Ca2+ channels (VDCCs) are critically involved in excitation contraction coupling and regulation of the force of contraction. An important mechanism contributing to the adaptation of heart function is modulation of the L-type Ca2+ current (I(Ca-L)) by hormones of the autonomous nervous system. The signaling pathways underlying this regulation in the adult heart are well understood. However, VDCC expression and its regulation in the embryonic heart are less understood. This report therefore provides a short overview of the current knowledge on this topic using embryonic stem cells and the mouse as model systems.
电压依赖性L型Ca2+通道（VDCCs）在兴奋-收缩偶联和收缩力调节中起关键作用。自主神经系统激素对L型Ca2+电流（I(Ca-L)）的调节是心脏功能适应的一个重要机制。在成体心脏中，这种调节的信号通路已得到充分了解。然而，VDCC在胚胎心脏中的表达及其调节尚不清楚。因此，本报告以胚胎干细胞和小鼠为模型系统，简要概述了关于这一主题的当前知识。
