老年人哮喘患者免疫功能的变化
Changes in immune function in asthma in the elderly.
作者信息
Mathur Sameer K, Nyenhuis Sharmilee M
出版信息
Aging health. 2009 Sep;5(4):551-559. doi: 10.2217/ahe.09.47.
Abstract
Asthma is an inflammatory disorder of the airway. The airway inflammation of asthma is typically an allergic inflammation characterized by cells and mediators described as a "Th2" inflammatory response. There is a growing body of evidence describing changes in the function of immune cells upon aging, a phenomenon referred to as "immunosenescence". Several studies utilizing animal models and human subjects with asthma have begun to explore age-related effects on the airway inflammation in asthma. This review explores the existing data on the presence and effects of immunosenescence or age-related changes in immune function in asthma.
摘要
哮喘是一种气道炎症性疾病。哮喘的气道炎症通常是一种过敏性炎症，其特征是细胞和介质呈现出“Th2”炎症反应。越来越多的证据描述了免疫细胞功能随衰老而发生的变化，这一现象被称为“免疫衰老”。几项利用动物模型和哮喘患者进行的研究已开始探索年龄对哮喘气道炎症的影响。本综述探讨了关于哮喘中免疫衰老的存在及其影响或免疫功能与年龄相关变化的现有数据。
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