Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Expert Rev Respir Med. 2023 May;17(5):351-364. doi: 10.1080/17476348.2023.2205127. Epub 2023 Apr 26.
Several immunological alterations that occur during pulmonary diseases often mimic alterations observed in the aged lung. From the molecular perspective, pulmonary diseases and aging partake in familiar mechanisms associated with significant dysregulation of the immune systems. Here, we summarized the findings of how aging alters immunity to respiratory conditions to identify age-impacted pathways and mechanisms that contribute to the development of pulmonary diseases.
The current review examines the impact of age-related molecular alterations in the aged immune system during various lung diseases, such as COPD, IPF, Asthma, and alongside many others that could possibly improve on current therapeutic interventions. Moreover, our increased understanding of this phenomenon may play a primary role in shaping immunomodulatory strategies to boost outcomes in the elderly. Here, the authors present new insights into the context of lung-related diseases and describe the alterations in the functioning of immune cells during various pulmonary conditions altered with age.
The expert opinion provided the concepts on how aging alters immunity during pulmonary conditions, and suggests the associated mechanisms during the development of lung diseases. As a result, it becomes important to comprehend the complex mechanism of aging in the immune lung system.
在肺部疾病期间发生的几种免疫学改变常常类似于在老年肺部中观察到的改变。从分子角度来看，肺部疾病和衰老参与了与免疫系统显著失调相关的常见机制。在这里，我们总结了衰老如何改变对呼吸状况的免疫反应，以确定影响肺部疾病发展的年龄相关途径和机制。
本综述检查了在各种肺部疾病（如 COPD、IPF、哮喘等）期间，年龄相关的分子改变对老年免疫系统的影响，以及可能改善当前治疗干预的许多其他疾病。此外，我们对这一现象的认识加深可能在塑造免疫调节策略方面发挥主要作用，以提高老年人的治疗效果。在这里，作者提供了有关与肺部疾病相关的新概念，并描述了随着年龄的增长，在各种与年龄相关的肺部疾病中免疫细胞功能的改变。
专家意见提供了关于衰老如何在肺部疾病期间改变免疫的概念，并提出了在肺部疾病发展过程中相关的机制。因此，了解免疫系统中衰老的复杂机制变得非常重要。
