凝血对多形核白细胞趋化活性产生的影响。
Coagulation impact on chemotactic activity generation for polymorphonuclear leukocytes.
作者信息
Morin A, Arvier M M, Doutremepuich F, Vigneron C
机构信息
Centre de Transfusion Sanguine, Vandoeuvre, France.
出版信息
Thromb Res. 1990 Sep 15;59(6):979-84. doi: 10.1016/0049-3848(90)90121-r.
Chemotactic technique in agarose gel has exposed the attractive properties of human alpha thrombin with respect to human polymorphonuclear leukocytes. The observed chemotaxis is maximal between 1.4.10-5 M and 1.6.10-5 M but extends from 2.8.10-6 M to 2.2.10-5 M. Human prothrombin, in an identical concentration zone as that studied for thrombin shows no chemotactic activity on the polymorphonuclear leukocytes. During coagulation the formed alpha thrombin attracts the polymorphonuclear leukocytes to it's formation site.
琼脂糖凝胶趋化技术已揭示人α-凝血酶对人多形核白细胞具有吸引特性。观察到的趋化作用在1.4×10⁻⁵ M至1.6×10⁻⁵ M之间最强，但范围从2.8×10⁻⁶ M至2.2×10⁻⁵ M。人凝血酶原在与研究凝血酶相同的浓度范围内，对多形核白细胞无趋化活性。在凝血过程中，形成的α-凝血酶将多形核白细胞吸引至其形成部位。
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