Kurihara A, Ojima F, Tsurufuji S
Biochem Biophys Res Commun. 1984 Mar 15;119(2):720-5. doi: 10.1016/s0006-291x(84)80310-1.
Rat polymorphonuclear leukocytes exposed to opsonised zymosan particles in vitro instantaneously and continuously release a chemotactic factor in the medium. The activity of this factor was mainly attributed to leukotriene B4, based on the data with high performance liquid chromatography. Preincubation of the cells with an antiinflammatory steroid, dexamethasone, at a dose of 0.25 micrograms/ml caused suppression in generation of the chemotactic factor from the leukocytes in a time-dependent manner.
体外暴露于调理酵母聚糖颗粒的大鼠多形核白细胞会立即且持续地在培养基中释放一种趋化因子。基于高效液相色谱的数据，该因子的活性主要归因于白三烯B4。用剂量为0.25微克/毫升的抗炎类固醇地塞米松对细胞进行预孵育，会以时间依赖性方式抑制白细胞产生趋化因子。
