Department of Anatomy, Embryology & Physiology, Academic Medical Center, Amsterdam, The Netherlands.
Reprod Toxicol. 2012 Sep;34(2):225-36. doi: 10.1016/j.reprotox.2012.05.087. Epub 2012 May 26.
Knowledge of complex morphogenetic processes that occur during embryonic development is essential for understanding anatomy and to get insight in the pathogenesis of congenital malformations. Understanding these processes can be facilitated by using a three-dimensional (3D) developmental series of human embryos, which we aim to create in this project. Digital images of serial sections of 34 human embryos of the Carnegie Collection between Carnegie stages 7 (15-17 days) and 23 (56-60 days) are used to create 3D reconstructions of different organ systems. The software package Amira is used to align the sections and to create the 3D reconstructions. In this midway evaluation we show the first results of the atlas, containing 34 embryos with more than 13.500 manually annotated sections. The 3D models can be interactively viewed within a 3D-pdf. This will be the first complete digital 3D human embryology atlas of this size, containing all developing organ systems.
了解胚胎发育过程中发生的复杂形态发生过程对于理解解剖结构和了解先天性畸形的发病机制至关重要。通过使用我们旨在在本项目中创建的人类胚胎的三维（3D）发育系列，可以促进对这些过程的理解。卡内基收藏馆的 34 个人类胚胎的连续切片的数字图像，从卡内基阶段 7（15-17 天）到 23（56-60 天），用于创建不同器官系统的 3D 重建。使用软件包 Amira 来对齐切片并创建 3D 重建。在这个中途评估中，我们展示了图谱的第一个结果，其中包含 34 个胚胎，有超过 13500 个手动注释的切片。3D 模型可以在 3D-pdf 中进行交互式查看。这将是第一个包含所有发育器官系统的这种规模的完整数字 3D 人类胚胎学图谱。
