Department of Neurology, Children's Hospital Boston, Boston, MA, USA.
Semin Pediatr Neurol. 2012 Mar;19(1):35-42. doi: 10.1016/j.spen.2012.02.014.
Newer treatments have resulted in increasing numbers of survivors of childhood cancer, for whom neurological and neurocognitive toxicity directly impacts overall functioning and quality of life. There are multiple disease- and host-related factors that influence the development of cancer-related neurocognitive dysfunction, which can progress over time and lead to significant functional impairments. This article provides an overview of the types of neurocognitive deficits seen in survivors of childhood brain tumors, the tools used to assess neurocognitive function, and the factors that impact its severity. This provides a framework for consideration of potential areas for primary prevention by reducing treatment-related toxicity as well as interventions, using behavioral and pharmacologic treatments.
新的治疗方法已经使越来越多的儿童癌症幸存者存活下来，他们的神经和神经认知毒性直接影响整体功能和生活质量。有多种疾病和宿主相关因素会影响癌症相关神经认知功能障碍的发展，这种障碍会随着时间的推移而逐渐加重，导致严重的功能障碍。本文概述了儿童脑瘤幸存者中出现的神经认知缺陷类型、用于评估神经认知功能的工具，以及影响其严重程度的因素。这为通过减少与治疗相关的毒性以及使用行为和药物治疗的干预措施来考虑进行初级预防的潜在领域提供了一个框架。
