Dinkel Andreas, Geinitz Hans, Ringel Florian, Herschbach Peter
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, Langerstraße 3, Munich.
Psychother Psychosom Med Psychol. 2012 Mar-Apr;62(3-4):89-94. doi: 10.1055/s-0032-1304650. Epub 2012 Apr 2.
This article reviews research on neurocognitive deficits in adult patients with malignant brain tumors, i. e. high-grade primary brain tumors and brain metastases. Brain tumor patients experience significant neurocognitive deficits, mainly in the domains of attention, memory, executive function and psychomotor function. Neurosurgical, radiotherapeutic or radiochemotherapeutic treatment regimens are often associated with a decline in cognitive functioning. However, such empirical observations are often confounded with the neurocognitive effects of tumor progression. Few studies investigated associations among neurocognitive deficits and distress. These studies revealed contradictory results. Similarly, research on neurocognitive deficits and health-related quality of life has resulted in equivocal evidence. Furthermore, convincing empirical evidence for the effectiveness of neurocognitive training in patients with high-grade brain tumors is lacking.
本文综述了成年恶性脑肿瘤患者，即高级别原发性脑肿瘤和脑转移瘤患者神经认知缺陷的研究。脑肿瘤患者存在明显的神经认知缺陷，主要表现在注意力、记忆力、执行功能和精神运动功能等方面。神经外科、放射治疗或放化疗治疗方案通常与认知功能下降有关。然而，这些经验性观察结果常常与肿瘤进展的神经认知效应相混淆。很少有研究调查神经认知缺陷与痛苦之间的关联。这些研究得出了相互矛盾的结果。同样，关于神经认知缺陷与健康相关生活质量的研究也产生了不明确的证据。此外，缺乏令人信服的经验证据来证明神经认知训练对高级别脑肿瘤患者的有效性。
