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本文引用的文献

1
Longchain polyunsaturated fatty acid supplementation in preterm infants.早产儿补充长链多不饱和脂肪酸
Cochrane Database Syst Rev. 2016 Dec 20;12(12):CD000375. doi: 10.1002/14651858.CD000375.pub5.
2
The role of meta-analysis in the evaluation of the effects of early nutrition on mental and motor development in children.荟萃分析在评估早期营养对儿童心理和运动发育影响中的作用。
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1889S-1895S. doi: 10.3945/ajcn.110.000653. Epub 2011 Apr 27.
3
Breastfeeding, brain activation to own infant cry, and maternal sensitivity.母乳喂养、大脑对自身婴儿哭声的激活与母亲敏感性。
J Child Psychol Psychiatry. 2011 Aug;52(8):907-15. doi: 10.1111/j.1469-7610.2011.02406.x. Epub 2011 Apr 18.
4
Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health.多不饱和脂肪酸代谢中的遗传变异及其对人类发育和健康的潜在相关性。
Matern Child Nutr. 2011 Apr;7 Suppl 2(Suppl 2):27-40. doi: 10.1111/j.1740-8709.2011.00319.x.
5
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.FADS1 和 FADS2 基因簇的变异体、血液中多不饱和脂肪酸水平与儿童生命最初 2 年内特应性皮炎的关系。
PLoS One. 2010 Oct 11;5(10):e13261. doi: 10.1371/journal.pone.0013261.
6
Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - Implications for dietary recommendations.二十二碳六烯酸（DHA）与中枢神经系统（CNS）的发育 - 对膳食建议的影响。
Biochimie. 2011 Jan;93(1):7-12. doi: 10.1016/j.biochi.2010.05.005. Epub 2010 May 15.
7
Docosahexaenoic acid and lactation.二十二碳六烯酸与哺乳期
Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):175-8. doi: 10.1016/j.plefa.2009.05.006. Epub 2009 Jul 24.
8
Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials.通过补充膳食二十二碳六烯酸和花生四烯酸优化足月儿的视力和认知：随机对照试验综述
Prostaglandins Leukot Essent Fatty Acids. 2009 Aug-Sep;81(2-3):151-8. doi: 10.1016/j.plefa.2009.05.003. Epub 2009 Jun 7.
9
Infant feeding and feeding transitions during the first year of life.生命第一年的婴儿喂养及喂养过渡
Pediatrics. 2008 Oct;122 Suppl 2:S36-42. doi: 10.1542/peds.2008-1315d.
10
Dietary omega 3 fatty acids and the developing brain.膳食中的欧米伽-3脂肪酸与发育中的大脑。
Brain Res. 2008 Oct 27;1237:35-43. doi: 10.1016/j.brainres.2008.08.078. Epub 2008 Sep 9.

配方奶粉中长链多不饱和脂肪酸补充与婴儿认知能力的荟萃分析。

Meta-analysis of long-chain polyunsaturated fatty acid supplementation of formula and infant cognition.

机构信息

Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA.

出版信息

Pediatrics. 2012 Jun;129(6):1141-9. doi: 10.1542/peds.2011-2127. Epub 2012 May 28.

DOI:10.1542/peds.2011-2127
PMID:22641753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3362904/
Abstract

BACKGROUND AND OBJECTIVE

Infant formula is supplemented with long-chain polyunsaturated fatty acids (LCPUFAs) because they are hypothesized to improve cognition. Several randomized controlled clinical trials have examined the effect of LCPUFA supplementation of infant formula on cognitive development. We conducted this meta-analysis to examine the efficacy of LCPUFA supplementation of infant formula on early cognitive development.

METHODS

Two authors searched PubMed, PsychInfo, and Scopus for randomized controlled clinical trials assessing the efficacy of LCPUFA supplementation of infant formulas on cognition. Our analysis was restricted to randomized controlled clinical trials that examined the effect of LCPUFA supplementation on infant cognition using Bayley Scales of Infant Development. Our primary outcome was the weighted mean difference in Bayley Scales of Infant Development score between infants fed formula supplemented with LCPUFA compared with unsupplemented formula. We conducted secondary subgroup analyses and meta-regression to examine the effects of study sample, LCPUFA dose, and trial methodologic quality on measured efficacy of supplementation.

RESULTS

Twelve trials involving 1802 infants met our inclusion criteria. Our meta-analysis demonstrated no significant effect of LCPUFA supplementation of formula on infant cognition. There was no significant heterogeneity or publication bias between trials. Secondary analysis failed to show any significant effect of LCPUFA dosing or prematurity status on supplementation efficacy.

CONCLUSIONS

LCPUFA supplementation of infant formulas failed to show any significant effect on improving early infant cognition. Further research is needed to determine if LCPUFA supplementation of infant formula has benefits for later cognitive development or other measures of neurodevelopment.

摘要

背景与目的

婴儿配方奶粉中添加长链多不饱和脂肪酸（LCPUFAs），因为它们被认为可以改善认知能力。已经有几项随机对照临床试验研究了婴儿配方奶粉中 LCPUFA 补充对认知发展的影响。我们进行了这项荟萃分析，以检验婴儿配方奶粉中 LCPUFA 补充对早期认知发展的功效。

方法

两位作者在 PubMed、PsychInfo 和 Scopus 上搜索了评估婴儿配方奶粉中 LCPUFA 补充对认知功效的随机对照临床试验。我们的分析仅限于使用贝利婴幼儿发展量表评估 LCPUFA 补充对婴儿认知影响的随机对照临床试验。我们的主要结局是接受 LCPUFA 补充的婴儿配方奶粉与未补充的配方奶粉相比，在贝利婴幼儿发展量表评分上的加权均数差值。我们进行了二次亚组分析和荟萃回归，以检验研究样本、LCPUFA 剂量和试验方法学质量对补充功效的影响。

结果

有 12 项涉及 1802 名婴儿的试验符合我们的纳入标准。我们的荟萃分析表明，配方奶粉中 LCPUFA 的补充对婴儿认知没有显著影响。试验之间没有显著的异质性或发表偏倚。二次分析未能显示 LCPUFA 剂量或早产儿状态对补充功效有任何显著影响。

结论

婴儿配方奶粉中 LCPUFA 的补充未能显示出对改善早期婴儿认知有任何显著效果。需要进一步研究以确定婴儿配方奶粉中 LCPUFA 的补充是否对后期认知发展或其他神经发育指标有益。