Illek Ia Iu, Bakhiev Kh B
Urol Nefrol (Mosk). 1990 Sep-Oct(5):38-40.
Studies showed that equivocal shifts occur in the functional condition of the thyroid in children with various clinical syndromes of acute glomerulonephritis and clinical forms of chronic glomerulonephritis. For instance, signs of increased functional activity of the thyroid are encountered in children with the nephritic syndrome of the acute and hematuria form of chronic glomerulonephritis, and signs of diminished thyroid function occur in patients with the nephrotic syndrome of the acute and nephrotic form of chronic glomerulonephritis, evidence of which are the corresponding changes of the content of protein-bound iodine and thyroid hormones in the blood serum. No essential changes are revealed in the functional condition of the thyroid in other syndromes of acute and forms of chronic glomerulonephritis. At the same time, signs of immunopathological changes of the thyroid are revealed in patients with various syndromes of acute and forms of chronic glomerulonephritis; these are manifested by the appearance of antithyroid antigens in the blood and increase of the neutrophil injuriousness index in the test with the antigen of this organ. The obtained data indicate that in planning complex therapy of children with glomerulonephritis due regard should be given to involvement of the thyroid in the pathological process and the character of its functional disorders in concrete clinical syndromes of acute and clinical forms of chronic glomerulonephritis.
研究表明，在患有各种急性肾小球肾炎临床综合征及慢性肾小球肾炎临床类型的儿童中，甲状腺的功能状态会出现不明确的变化。例如，在急性肾小球肾炎的肾病综合征及慢性肾小球肾炎的血尿型患儿中，会出现甲状腺功能活动增强的迹象；而在急性肾小球肾炎的肾病综合征及慢性肾小球肾炎的肾病型患者中，则会出现甲状腺功能减退的迹象，血清中蛋白结合碘及甲状腺激素含量的相应变化即为证据。在急性肾小球肾炎的其他综合征及慢性肾小球肾炎的其他类型中，未发现甲状腺功能状态有本质性变化。同时，在患有各种急性肾小球肾炎临床综合征及慢性肾小球肾炎临床类型的患者中，发现了甲状腺免疫病理变化的迹象；这些变化表现为血液中出现抗甲状腺抗原，以及在用该器官抗原进行检测时中性粒细胞损伤指数升高。所获数据表明，在为患有肾小球肾炎的儿童制定综合治疗方案时，应充分考虑甲状腺参与病理过程的情况及其在急性肾小球肾炎具体临床综合征及慢性肾小球肾炎临床类型中的功能紊乱特征。
