Kucherenko A G, Iatsyk P K, Markov Kh M, Isakov A
Urol Nefrol (Mosk). 1990 Sep-Oct(5):41-4.
The excretion of renal prostaglandins (PGE, PGF2 alpha, 6-keto-PGE1 alpha and TKB2) was studied in 45 children with chronic obstructive pyelonephritis in the presence of vesicoureteral reflux with account for the disease stage (partial remission--group I; total clinical and laboratory remission--group II) in various periods of surgical corrections of the impaired urodynamics in the area of vesicoureteral segments (in the early postoperative period of 12-14 days after the surgery; in the follow-up period of 6-12 months after the surgery). Preoperative observation of Group I children revealed a significant decrease in urinary PGF2 alpha excretion in the presence of an increase in the circadian TKB2 and 6-keto-PGF1 alpha excretion, whereas the patients from Group II who had normal levels of TKB2 and 6-keto-PGF1 alpha excretion, the levels of PGE and PGF2 alpha were lowered. The retention of sodium was documented in both groups. There was a total recovery of renal sodium and water excretion 6-12 months after the surgery. Children without the urinary syndrome (group II) demonstrated normalization of all secreted prostanoids, whereas in those with pronounced severity of pyelonephritis (group I), the excretion of sodium and diuresis were likely to be provided by hyperproduction of vasodilating sodium and diuretic PGE.
对45例伴有膀胱输尿管反流的慢性阻塞性肾盂肾炎患儿的肾前列腺素（前列腺素E、前列腺素F2α、6-酮-前列腺素E1α和血栓素B2）排泄情况进行了研究，研究考虑了疾病阶段（部分缓解——I组；完全临床和实验室缓解——II组），观察时间为膀胱输尿管段尿动力学受损的不同手术矫正时期（术后12 - 14天的早期术后阶段；术后6 - 12个月的随访阶段）。对I组患儿术前观察发现，昼夜尿血栓素B2和6-酮-前列腺素F1α排泄增加的同时，尿前列腺素F2α排泄显著减少，而II组患儿血栓素B2和6-酮-前列腺素F1α排泄水平正常，但前列腺素E和前列腺素F2α水平降低。两组均有钠潴留情况。术后6 - 12个月肾钠和水排泄完全恢复。无尿综合征的患儿（II组）所有分泌的前列腺素均恢复正常，而肾盂肾炎严重程度明显的患儿（I组），钠排泄和利尿可能由血管舒张性钠和利尿性前列腺素E的过度产生来实现。
