[膳食脂肪水平对大鼠异生物代谢酶活性和抗氧化酶的影响]
[Effects of dietary fat level on the xenobiotic metabolism enzymes activity and antioxidant enzymes in rats].
作者信息
Kravchenko L V, Aksenov I V, Trusov N V, Guseva G V, Avren'eva L I
出版信息
Vopr Pitan. 2012;81(1):24-9.
Male Wistar rats received fat-free diet or diets containing 5, 10 and 30% of fat (sunflower oil + lard, 1:1) for 4 weeks. The direct relationship between dietary fat level and ethoxyresorufin O-dealkylase activity of CYP1A1, methoxyresorufin O-dealkylase activity of CYP1A2, pentoxyresorufin O-dealkylase activity of CYP2B1 and testosterone 6beta-hydroxylase activity of CYP3A was found. Activities of key enzymes of phase II xenobiotic metabolism (total activity of glutathione transferase, activity of UDP-glucuronosyle transferase) and antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, paraoxonase-1 and heme oxygenase-1) also increased with higher dietary fat level.
雄性Wistar大鼠接受无脂肪饮食或含有5%、10%和30%脂肪（向日葵油+猪油，1:1）的饮食，持续4周。研究发现饮食脂肪水平与细胞色素P450 1A1的乙氧基异吩恶唑酮O-脱烷基酶活性、细胞色素P450 1A2的甲氧基异吩恶唑酮O-脱烷基酶活性、细胞色素P450 2B1的戊氧基异吩恶唑酮O-脱烷基酶活性以及细胞色素P450 3A的睾酮6β-羟化酶活性之间存在直接关系。随着饮食脂肪水平的升高，II期外源性物质代谢关键酶（谷胱甘肽转移酶的总活性、UDP-葡萄糖醛酸基转移酶的活性）和抗氧化酶（过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、对氧磷酶-1和血红素加氧酶-1）的活性也会增加。
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