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Is there value in kinetic modeling of thrombin generation? Yes.
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Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile.
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A comprehensive model for the humoral coagulation network in humans.
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Factor XI and traveling waves: the key to understanding coagulation in hemophilia?
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Comparing thrombin generation in patients with hemophilia A and patients on vitamin K antagonists.
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9
Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation.
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Critical evaluation of kinetic schemes for coagulation.
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Computationally Driven Discovery in Coagulation.
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Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis.
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Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation.
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Global assays of hemostasis.
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Systems biology of coagulation.
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本文引用的文献

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Defining the boundaries of normal thrombin generation: investigations into hemostasis.
PLoS One. 2012;7(2):e30385. doi: 10.1371/journal.pone.0030385. Epub 2012 Feb 2.
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Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.
PLoS One. 2012;7(1):e29178. doi: 10.1371/journal.pone.0029178. Epub 2012 Jan 11.
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Blood clot formation under flow: the importance of factor XI depends strongly on platelet count.
Biophys J. 2012 Jan 4;102(1):10-8. doi: 10.1016/j.bpj.2011.10.048. Epub 2012 Jan 3.
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Membrane binding events in the initiation and propagation phases of tissue factor-initiated zymogen activation under flow.
J Biol Chem. 2012 Feb 17;287(8):5225-34. doi: 10.1074/jbc.M111.302075. Epub 2011 Dec 20.
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Anticoagulants and the propagation phase of thrombin generation.
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Thrombin generation in hemorrhage control and vascular occlusion.
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Kinetic modeling sheds light on the mode of action of recombinant factor VIIa on thrombin generation.
Thromb Res. 2011 Oct;128(4):381-90. doi: 10.1016/j.thromres.2011.05.013. Epub 2011 Jun 8.
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Computational approaches to studying thrombus development.
Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):500-5. doi: 10.1161/ATVBAHA.110.213397.
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Dilutional control of prothrombin activation at physiologically relevant shear rates.
Biophys J. 2011 Feb 2;100(3):765-773. doi: 10.1016/j.bpj.2010.12.3720.
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Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.
PLoS Comput Biol. 2010 Sep 30;6(9):e1000950. doi: 10.1371/journal.pcbi.1000950.

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