Alexiou George A, Tsiouris Spyridon, Voulgaris Spyridon, Kyritsis Athanasios P, Fotopoulos Andreas D
Department of Neurosurgery, University Hospital of Ioannina, Ioannina, Greece.
Curr Radiopharm. 2012 Oct;5(4):308-13. doi: 10.2174/1874471011205040308.
Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor occurring during adulthood. The incidence of GBM is nearly 5 cases per 100,000 population per year. The standard of care for newly diagnosed GBM includes surgical resection when possible, followed by radiotherapy and concomitant and adjuvant chemotherapy with temozolomide. Imaging modalities used in nuclear medicine, namely positron emission tomography (PET) and single-photon emission computed tomography (SPECT) have been employed towards the evaluation of brain tumors. Herewith, we discuss the value of the above imaging techniques in the assessment of GBM aggressiveness, in the distinction of treatment induced necrosis from glioma recurrence, in the estimation of overall prognosis and in the evaluation of treatment response in patients with GBM.
多形性胶质母细胞瘤（GBM）是成年期最常见且恶性程度最高的原发性脑肿瘤。GBM的发病率约为每年每10万人中有5例。新诊断GBM的标准治疗包括在可能的情况下进行手术切除，随后进行放疗以及同步和辅助使用替莫唑胺化疗。核医学中使用的成像方式，即正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）已用于脑肿瘤的评估。在此，我们讨论上述成像技术在评估GBM侵袭性、区分治疗引起的坏死与胶质瘤复发、估计总体预后以及评估GBM患者治疗反应方面的价值。
