Jin Fangli, Cao Mingbo, Bai Yangqiu, Zhang Yanrui, Yang Yuxiu, Zhang Bingyong
Department of Gastroenterology, The First Affiliated Hospital, Zhengzhou University College of Medicine, Zhengzhou, Henan 450052, China.
Discov Med. 2012 May;13(72):369-73.
Analysis of the efficacy and timing of plasma exchange (PE) in the treatment of acute fatty liver of pregnancy (AFLP).
The clinical data of 39 cases of AFLP treated with PE from September 2004 to March 2011 include symptoms, physical signs, adverse effects, and all relevant laboratory test results before and after PE.
(1) Adverse reactions during PE were generally mild and tolerable, and no patients discontinued treatment due to adverse events; symptoms, physical signs, and liver and kidney functions improved significantly after PE (P<0.05); (2) of the 39 cases treated, 37 were cured, 2 died, with a cure rate of 94.87%; (3) of the 37 cases cured, the sooner a patient received PE the faster the recovery and the fewer number of PEs needed for a complete recovery (P<0.01).
Treatment of AFLP by PE is safe and effective, and timely application of PE in the early phase of the disease can effectively halt and reverse the progression of AFLP.
分析血浆置换（PE）治疗妊娠急性脂肪肝（AFLP）的疗效及时机。
选取2004年9月至2011年3月间39例接受PE治疗的AFLP患者的临床资料，包括症状、体征、不良反应以及PE前后所有相关实验室检查结果。
（1）PE过程中的不良反应一般较轻且可耐受，无患者因不良事件而中断治疗；PE后症状、体征及肝肾功能均有显著改善（P<0.05）；（2）39例接受治疗的患者中，37例治愈，2例死亡，治愈率为94.87%；（3）在37例治愈的患者中，患者接受PE越早，恢复越快，完全恢复所需的PE次数越少（P<0.01）。
PE治疗AFLP安全有效，在疾病早期及时应用PE可有效阻止并逆转AFLP的进展。
