Department of Infectious Diseases, Xiangya Hospital, Central South University, Kaifu District, Xiangya Road 87, Changsha, 410008, China.
Key Laboratory of Viral Hepatitis, Changsha, Hunan, China.
BMC Pregnancy Childbirth. 2020 Oct 7;20(1):601. doi: 10.1186/s12884-020-03287-y.
Acute fatty liver of pregnancy (AFLP) is a potentially lethal condition of pregnant women with a high mortality rate. Potential predictors related to postpartum recovery time and prognostic factors of AFLP are still unclear. This study aimed to evaluate potential predictors for prognosis and postpartum recovery time of AFLP.
We retrospectively analyzed the clinical data of 76 AFLP patients in our hospital from 2002 to 2017 and investigated potential predictors using univariate analysis and multivariate logistic regression analysis.
Hepatic encephalopathy (HE) was found to be associated with prognosis in AFLP patients (P = 0.005, OR = 26.844). The postpartum recovery time analysis showed that AFLP patients with a age < 25 had the shortest recovery time, but no significant difference (P = 0.134, OR = 5.952). The postpartum recovery time of patients with liver failure (LF) was significantly prolonged compared to those without LF (P = 0.036, OR = 10.052). Cryoprecipitate, and plasma infusion showed no significant effect on prognosis or recovery time. Artificial liver support therapy (ALST) had no effect on prognosis, but it might affect postpartum recovery time with no statistical significance (P = 0.128, OR = 5.470).
HE is a potential predictor for prognosis of AFLP. LF is a potential predictor for postpartum recovery time.
妊娠急性脂肪肝（AFLP）是一种孕妇潜在的致命疾病，死亡率很高。与产后恢复时间相关的潜在预测因素和 AFLP 的预后因素仍不清楚。本研究旨在评估 AFLP 的预后和产后恢复时间的潜在预测因素。
我们回顾性分析了 2002 年至 2017 年我院 76 例 AFLP 患者的临床资料，采用单因素分析和多因素 logistic 回归分析探讨潜在的预测因素。
肝性脑病（HE）与 AFLP 患者的预后相关（P=0.005，OR=26.844）。产后恢复时间分析表明，年龄<25 岁的 AFLP 患者恢复时间最短，但无显著差异（P=0.134，OR=5.952）。肝功能衰竭（LF）患者的产后恢复时间明显长于无 LF 患者（P=0.036，OR=10.052）。冷沉淀和血浆输注对预后或恢复时间无显著影响。人工肝支持治疗（ALST）对预后无影响，但对产后恢复时间的影响无统计学意义（P=0.128，OR=5.470）。
HE 是 AFLP 预后的一个潜在预测因素。LF 是产后恢复时间的一个潜在预测因素。
