Psychology Department, Laurentian University, Sudbury, Ontario, Canada.
Intellect Dev Disabil. 2012 Apr;50(2):155-68. doi: 10.1352/1934-9556-50.2.155.
Specific genetic syndromes affect individuals' sexual development, experiences, and fertility. Individuals with specific syndromes can also display inappropriate sexual behavior resulting from vulnerabilities presented by their genetic makeup. Using clinical case studies, we discuss the specific impact that Down, Prader-Willi, and Williams syndromes can have on sexual development and behavior. Applying a biopsychosocial approach, we present the primary sexual effects, such as delayed sexual development and infertility. These genetic syndromes are also associated with challenges that are not specifically sexual in nature but that affect sexual expression, such as self-injury, mental health issues, or epilepsy. Medication side effects are also discussed. We conclude with treatment recommendations for individuals with sexual challenges, considering the unique effects of these three syndromes on sexuality.
特定的遗传综合征会影响个体的性发育、性体验和生育能力。具有特定综合征的个体也可能表现出不适当的性行为，这是由其遗传构成带来的脆弱性导致的。我们通过临床案例研究，讨论了唐氏综合征、普拉德-威利综合征和威廉姆斯综合征对性发育和行为的具体影响。我们采用生物心理社会方法，介绍了主要的性影响，如性发育延迟和不育。这些遗传综合征还与非特异性的性表达相关的挑战有关，如自残、心理健康问题或癫痫。药物的副作用也在讨论之列。我们根据这些三种综合征对性的独特影响，为有性挑战的个体提出了治疗建议。
