Romero Yannick, Calvel Pierre, Nef Serge
Département de médecine génétique et développement, faculté de médecine, université de Genève, 1, rue Michel-Servet, 1211 Genève 4, Suisse.
Med Sci (Paris). 2012 May;28(5):490-6. doi: 10.1051/medsci/2012285013. Epub 2012 May 30.
The continuous production of spermatozoa is a tightly regulated biological process, both at the transcriptional and post-transcriptional levels. Recently, different classes of small non-coding RNAs have emerged as important regulators of spermatogenesis. Available molecular and genetic data, although still fragmented, underscore their crucial role in regulating the fine tuning of gene expression required for testicular function. Here, we review the latest advances accomplished in this domain, spanning from the biogenesis of these small non-coding RNAs to their roles in male reproductive function.
精子的持续产生是一个在转录和转录后水平都受到严格调控的生物学过程。最近，不同类别的小非编码RNA已成为精子发生的重要调节因子。现有的分子和遗传数据虽然仍然零散，但强调了它们在调节睾丸功能所需基因表达的精细调控中的关键作用。在此，我们综述了该领域取得的最新进展，涵盖了这些小非编码RNA的生物合成及其在雄性生殖功能中的作用。
