Kumari J O
Department of ENT, Co-Operative Medical College, Kochi, Kerala, India.
J Laryngol Otol. 2012 Jun;126(6):630-2. doi: 10.1017/S0022215112000552.
Rhinoscleroma and Rosai-Dorfman disease have been reported to coexist in the same patient at different sites. Rosai-Dorfman disease may have an aetiological relationship with rhinoscleroma, although this has not yet been proved.
A case of a 42-year-old woman with recurrent nasal masses is presented, with histopathological proof of both conditions coexisting in the same nasal lesion.
The aetiopathology, clinical features and treatment of both diseases are discussed and a literature survey is reported. Histologically, the presence of Mikulicz cells with entrapped, rod-like, Gram-negative bacilli and Russell bodies suggests rhinoscleroma. Emperipolesis and S-100-positive histiocytes confirm the diagnosis of Rosai-Dorfman disease. The presence of both in the same slides from affected tissues has never been demonstrated before. In the light of this evidence, the author believes that rhinoscleroma must be considered in the aetiology of Rosai-Dorfman disease.
据报道，鼻硬结病和罗萨伊-多夫曼病可在同一患者的不同部位同时存在。罗萨伊-多夫曼病可能与鼻硬结病存在病因学关系，尽管尚未得到证实。
本文介绍了一例42岁复发性鼻腔肿物女性患者，其同一鼻腔病变经组织病理学证实同时存在这两种疾病。
对这两种疾病的病因病理、临床特征及治疗方法进行了讨论，并报告了文献综述。组织学上，存在含有被包裹的杆状革兰氏阴性杆菌的米库利奇细胞和拉塞尔小体提示为鼻硬结病。血细胞吞噬现象和S-100阳性组织细胞可确诊罗萨伊-多夫曼病。此前从未在受累组织的同一切片中同时发现这两种情况。鉴于此证据，作者认为在罗萨伊-多夫曼病的病因学中必须考虑鼻硬结病。
