Reid H L, Memeh C U
Department of Physiology, School of Medicine, College of Medical Sciences, University of Benin, Nigeria.
West Indian Med J. 1990 Sep;39(3):148-52.
Alterations in Relative Plasma Viscosity (RPV) and Plasma Fibrinogen Concentration (PFC) were compared in 24 insulin-dependent (IDDM) and 33 non-insulin-dependent (NIDDM) black Nigerian diabetics, during the course of treatment. Both PFC and RPV were significantly (p less than 0.001) increased in the diabetics, as a group, compared to a non-diabetic control group. PFC and RPV showed consistently marginal, though insignificant, increases in the IDDM vs NIDDM. Hypertensive diabetics, as a group, had significantly greater PFC (p less than 0.025), and RPV (p less than 0.025) than normotensive diabetics. Although PFC was significantly (p less than 0.05) raised in hypertensive IDDM, there was no marked change in RPV, compared to normotensive IDDM. Neither PFC nor RPV revealed a significant change between hypertensive and normotensive NIDDM. The implication of the present findings is that insulin-dependent diabetics may be more prone than non-insulin-dependent diabetics to develop haemorheological and hence circulatory disorders.
在治疗过程中，对24名胰岛素依赖型（IDDM）和33名非胰岛素依赖型（NIDDM）的尼日利亚黑人糖尿病患者的相对血浆粘度（RPV）和血浆纤维蛋白原浓度（PFC）变化进行了比较。与非糖尿病对照组相比，糖尿病患者作为一个整体，其PFC和RPV均显著升高（p<0.001）。在IDDM与NIDDM患者中，PFC和RPV始终呈现出轻微但不显著的升高。高血压糖尿病患者作为一个整体，其PFC（p<0.025）和RPV（p<0.025）显著高于血压正常的糖尿病患者。尽管高血压IDDM患者的PFC显著升高（p<0.05），但与血压正常的IDDM患者相比，RPV没有明显变化。高血压和血压正常的NIDDM患者之间，PFC和RPV均未显示出显著变化。本研究结果表明，胰岛素依赖型糖尿病患者可能比非胰岛素依赖型糖尿病患者更容易出现血液流变学异常，进而引发循环系统疾病。
