Kostron H, Daxenbichler G, Maier H
Universitätsklinik für Neurochirurgie, Innsbruck.
Wien Klin Wochenschr. 1990 Sep 28;102(18):525-8.
Cytosolic oestrogen and progesterone receptors (ER and PR) were determined in 58 primary and 13 recurrent meningiomas and related to their histological and clinical features. ER levels were low or not detectable (range 0-34 fmol/mg prot., median 0 fmol), whereas considerable amounts of PR were found in 69% of primary tumours (range 0-583 fmol/mg prot., median 72 fmol) and in 5/5 long-term recurrences (range 69-505 fmol/mg prot., median 143). Eight tumours recurred within a short-term period (less than 5 years) with a low PR expression (range 0-34 fmol/mg prot., median 0 fmol) and all presented raised cellularity and mitotic rate ("atypical" meningioma) or criteria of definitely malignant meningioma. The primary tumours of the short-term recurrences were not available for receptor analysis; however, they also were either "atypical" or anaplastic meningiomas. Long-term recurrences never displayed other than classical histology. From our results we conclude that polymorphy, as well as a lack of PR are strong indicators for short-term recurrence.
在58例原发性和13例复发性脑膜瘤中检测了胞质雌激素和孕激素受体（ER和PR），并将其与组织学和临床特征相关联。ER水平较低或无法检测到（范围为0 - 34 fmol/mg蛋白，中位数为0 fmol），而在69%的原发性肿瘤中发现了大量PR（范围为0 - 583 fmol/mg蛋白，中位数为72 fmol），在5例长期复发肿瘤中有5例检测到PR（范围为69 - 505 fmol/mg蛋白，中位数为143）。8例肿瘤在短期内（不到5年）复发，PR表达较低（范围为0 - 34 fmol/mg蛋白，中位数为0 fmol），所有这些肿瘤均表现为细胞增多和有丝分裂率升高（“非典型”脑膜瘤）或明确的恶性脑膜瘤标准。短期复发肿瘤的原发性肿瘤无法进行受体分析；然而，它们也均为“非典型”或间变性脑膜瘤。长期复发肿瘤除经典组织学外未表现出其他特征。根据我们的结果，我们得出结论，多形性以及PR缺乏是短期复发的有力指标。
