Simon M, Vigneswaran N
Dermatologische Universitäts-Klinik Erlangen.
Z Hautkr. 1990 Sep;65(9):817-9.
In 15 patients suffering from oral lichen planus (OLP), we took biopsies of both involved and noninvolved oral mucosa. The specimens were immunohistochemically studied with regard to the expression of beta-2-microglobulin (beta 2-M). In contrast to noninvolved mucosa, we proved definite beta 2-M expression in keratinocytes from OLP lesions. Our findings agree with the assumption that an autoimmunological process is involved in the pathogenesis of OLP.
在15例口腔扁平苔藓（OLP）患者中，我们对受累和未受累的口腔黏膜均进行了活检。对标本进行免疫组织化学研究，以观察β2-微球蛋白（β2-M）的表达情况。与未受累黏膜相比，我们证实在OLP病变的角质形成细胞中有明确的β2-M表达。我们的研究结果支持了OLP发病机制中涉及自身免疫过程这一假设。
