[口腔扁平苔藓中β2-微球蛋白的表达]
[Beta-2-microglobulin expression in oral lichen planus].
作者信息
Simon M, Vigneswaran N
机构信息
Dermatologische Universitäts-Klinik Erlangen.
出版信息
Z Hautkr. 1990 Sep;65(9):817-9.
PMID:2264371
Abstract
In 15 patients suffering from oral lichen planus (OLP), we took biopsies of both involved and noninvolved oral mucosa. The specimens were immunohistochemically studied with regard to the expression of beta-2-microglobulin (beta 2-M). In contrast to noninvolved mucosa, we proved definite beta 2-M expression in keratinocytes from OLP lesions. Our findings agree with the assumption that an autoimmunological process is involved in the pathogenesis of OLP.
摘要
在15例口腔扁平苔藓（OLP）患者中，我们对受累和未受累的口腔黏膜均进行了活检。对标本进行免疫组织化学研究，以观察β2-微球蛋白（β2-M）的表达情况。与未受累黏膜相比，我们证实在OLP病变的角质形成细胞中有明确的β2-M表达。我们的研究结果支持了OLP发病机制中涉及自身免疫过程这一假设。
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