Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan.
Antiviral Res. 2012 Aug;95(2):128-34. doi: 10.1016/j.antiviral.2012.05.009. Epub 2012 May 27.
Enterovirus 71 (EV 71), the newest member of Enteroviridae, is notorious for its etiological role in epidemics of the hand-foot-and-mouth disease, particularly in association with fatal neurological complications in young children. Searching for new and more effective agents against EV 71 infections has never relented as corresponding vaccines or antiviral drugs remain unavailable. Sulfated polysaccharides from seaweed are known to possess a broad range of biological activities across anti-virus, anti-tumor, immunomodulation, anti-coagulation, etc. In this study, we report kappa carrageenan also has a strong and effective anti-EV 71 activity able to reduce plaque formation, prevent viral replication before or during viral adsorption, as well as inhibit EV 71-induced apoptosis. In virus binding assay, kappa carrageenan was shown able to bind EV 71 firmly, forming carrageenan-viruses complexes, whereby the virus-receptor interaction is likely disrupted. Added together, kappa carrageenan may be an ideal candidate worthwhile to develop into anti-EV 71 agents.
肠道病毒 71 型（EV 71）是肠道病毒科的最新成员，因其在手足口病流行中的病因作用而臭名昭著，尤其是与幼儿致命的神经并发症有关。由于没有相应的疫苗或抗病毒药物，寻找新的、更有效的针对 EV 71 感染的药物一直没有停止。海藻中的硫酸多糖具有广泛的生物活性，包括抗病毒、抗肿瘤、免疫调节、抗凝等。在这项研究中，我们报告角叉菜胶也具有很强的抗 EV 71 活性，能够减少斑块形成，在病毒吸附前或吸附时阻止病毒复制，并抑制 EV 71 诱导的细胞凋亡。在病毒结合实验中，角叉菜胶被证明能够牢固地结合 EV 71，形成角叉菜胶-病毒复合物，从而可能破坏病毒-受体相互作用。综上所述，角叉菜胶可能是一种很有前途的抗 EV 71 药物。
