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2
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Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae.肺炎克雷伯菌中新型 AraC 家族多重耐药调节子 RarA 的特性研究。
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Characterization of Tigecycline Resistance Among Tigecycline Non-susceptible Isolates From Humans, Food-Producing Animals, and Selection Assay.对来自人类、食用动物的替加环素不敏感菌株的替加环素耐药性特征分析及筛选试验
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本文引用的文献

1
Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae.肺炎克雷伯菌中新型 AraC 家族多重耐药调节子 RarA 的特性研究。
Antimicrob Agents Chemother. 2012 Aug;56(8):4450-8. doi: 10.1128/AAC.00456-12. Epub 2012 May 29.
2
Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae.肺炎克雷伯菌 ramA 基因座的遗传调控及其在临床分离株中的表达。
Int J Antimicrob Agents. 2011 Jul;38(1):39-45. doi: 10.1016/j.ijantimicag.2011.02.012. Epub 2011 Apr 22.
3
First case of resistance to tigecycline by Klebsiella pneumoniae in a European University Hospital.欧洲一所大学医院中肺炎克雷伯菌对替加环素耐药的首例病例。
Indian J Med Microbiol. 2011 Jan-Mar;29(1):78-9. doi: 10.4103/0255-0857.76535.
4
Evolution of tigecycline resistance in Klebsiella pneumoniae in a single patient.一名患者肺炎克雷伯菌对替加环素耐药性的演变
Ann Saudi Med. 2010 Sep-Oct;30(5):404-7. doi: 10.4103/0256-4947.67087.
5
Emergence of tigecycline resistance amongst multi-drug resistant gram negative isolates in a multi-disciplinary hospital.一家多学科医院中多重耐药革兰氏阴性菌分离株对替加环素耐药性的出现。
J Infect. 2010 Oct;61(4):358-9. doi: 10.1016/j.jinf.2010.07.012. Epub 2010 Jul 27.
6
Emergence of AcrAB-mediated tigecycline resistance in a clinical isolate of Enterobacter cloacae during ciprofloxacin treatment.在环丙沙星治疗期间，阴沟肠杆菌临床分离株中出现了 AcrAB 介导的替加环素耐药性。
Int J Antimicrob Agents. 2010 May;35(5):478-81. doi: 10.1016/j.ijantimicag.2010.01.011. Epub 2010 Feb 26.
7
Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline.用替加环素治疗多重耐药革兰阴性菌严重感染的临床和微生物学结果
Clin Infect Dis. 2008 Feb 15;46(4):567-70. doi: 10.1086/526775.
8
Substrate specificity of the OqxAB multidrug resistance pump in Escherichia coli and selected enteric bacteria.大肠杆菌及部分肠道细菌中OqxAB多药耐药泵的底物特异性
J Antimicrob Chemother. 2007 Jul;60(1):145-7. doi: 10.1093/jac/dkm167. Epub 2007 May 24.
9
Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.转录激活因子RamA对肺炎克雷伯菌多药外排泵AcrAB表达及替加环素敏感性的影响
Antimicrob Agents Chemother. 2005 Mar;49(3):1017-22. doi: 10.1128/AAC.49.3.1017-1022.2005.
10
Conjugative plasmid conferring resistance to olaquindox.携带对喹乙醇耐药性的接合质粒。
Antimicrob Agents Chemother. 2003 Feb;47(2):798-9. doi: 10.1128/AAC.47.2.798-799.2003.

肺炎克雷伯菌中的替加环素耐药性可以独立于 ramA 基因发生。

Tigecycline resistance can occur independently of the ramA gene in Klebsiella pneumoniae.

机构信息

Centre for Infection and Immunity, Queen's University Belfast, Medical Biology Centre, Belfast, United Kingdom.

出版信息

Antimicrob Agents Chemother. 2012 Aug;56(8):4466-7. doi: 10.1128/AAC.06224-11. Epub 2012 May 29.

DOI:10.1128/AAC.06224-11
PMID:22644034
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421586/
Abstract

Tigecycline resistance in Klebsiella pneumoniae results from ramA upregulation that causes the overexpression of the efflux pump, AcrAB-TolC. Tigecycline mutants, derived from Ecl8ΔramA, can exhibit a multidrug resistance phenotype due to increased transcription of the marA, rarA, acrAB, and oqxAB genes. These findings support the idea that tigecycline or multidrug resistance in K. pneumoniae, first, is not solely dependent on the ramA gene, and second, can arise via alternative regulatory pathways in K. pneumoniae.

摘要

肺炎克雷伯菌对替加环素的耐药性源于 ramA 的上调，导致外排泵 AcrAB-TolC 的过度表达。源自 Ecl8ΔramA 的替加环素突变体由于 marA、rarA、acrAB 和 oqxAB 基因转录增加，可表现出多药耐药表型。这些发现支持以下观点：首先，肺炎克雷伯菌对替加环素或多药耐药性并非仅依赖于 ramA 基因，其次，可通过肺炎克雷伯菌中的替代调控途径产生。