Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133 Milan, Italy.
Neurol Sci. 2012 May;33 Suppl 1:S169-71. doi: 10.1007/s10072-012-1076-z.
This study aims to compare disability and mood state in patients with episodic (EM) and chronic migraine associated to medication overuse (CM-MO), and to assess the relationships between the two outcomes. Patients, matched for age and gender, were administered the MIDAS, the WHO-DAS-2 and BDI-2. Difference between EM and CM-MO was assessed with the Kolmogorov-Smirnov Test; difference in distribution of patients with severe disability and low mood was tested with contingency coefficient; the correlation between MIDAS, WHO-DAS-2 and BDI-2 was tested with Spearman's index. Seventy patients were enrolled: CM-MO patients reported higher BDI-2 scores and higher MIDAS and WHO-DAS-2 scores, and were more likely to have severe disability and low mood state than those with EM; BDI-2 scores were correlated with disability scores, particularly with WHO-DAS-2. The study shows that disability and mood state are negatively impacted by the presence of more frequent headaches and by the overuse of acute medications.
本研究旨在比较发作性偏头痛（EM）和药物过度使用性偏头痛（CM-MO）患者的残疾和情绪状态，并评估这两个结果之间的关系。患者按年龄和性别匹配，接受了 MIDAS、WHO-DAS-2 和 BDI-2 评估。使用 Kolmogorov-Smirnov 检验比较 EM 和 CM-MO 之间的差异；使用列联系数检验严重残疾和情绪低落患者分布的差异；使用 Spearman 指数检验 MIDAS、WHO-DAS-2 和 BDI-2 之间的相关性。共纳入 70 例患者：CM-MO 患者的 BDI-2 评分较高，MIDAS 和 WHO-DAS-2 评分也较高，且与 EM 患者相比，更有可能出现严重残疾和情绪低落状态；BDI-2 评分与残疾评分相关，尤其是与 WHO-DAS-2 相关。研究表明，更频繁的头痛和过度使用急性药物会对残疾和情绪状态产生负面影响。
