Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy,
Qual Life Res. 2014 May;23(4):1273-7. doi: 10.1007/s11136-013-0556-9. Epub 2013 Oct 16.
The purpose of the study is to assess validity, reliability and factor structure of the Italian version of Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) in patients suffering from chronic migraine (CM) with a history of medication overuse (MO).
Patients were enrolled at hospital admission for withdrawal from MO. Factor analysis was used to confirm the latent structure of the MSQ. Reliability was measured with Cronbach's alpha coefficient, item-total correlation and inter-item correlation. Construct validity was assessed with Pearson's coefficient and known-group analysis.
The three-factor structure is basically confirmed. Cronbach's alpha varied between 0.85 and 0.92; item-total correlations were on average higher than 0.70; average inter-item correlation ranged between 0.63 and 0.65. Correlations were all significant; known-group analysis shows that MSQ score was lower consistently with disease severity.
Our findings confirm the factor structure, reliability and validity of the MSQ and expand results of previous validation studies to the Italian language and to a group of patients with severe CM requiring withdrawal treatment for MO.
本研究旨在评估有药物过度使用史的慢性偏头痛（CM）患者使用偏头痛特异性生活质量问卷 2.1 版（MSQ）意大利语版的效度、信度和因子结构。
患者在入院接受药物戒断治疗时入组。采用因子分析来确认 MSQ 的潜在结构。采用 Cronbach's alpha 系数、条目-总分相关性和条目间相关性来衡量信度。采用 Pearson 系数和已知组分析评估结构效度。
基本证实了三因素结构。Cronbach's alpha 在 0.85 到 0.92 之间；条目-总分相关性平均高于 0.70；平均条目间相关性在 0.63 到 0.65 之间。相关性均有统计学意义；已知组分析表明，MSQ 评分随着疾病严重程度的增加而持续降低。
本研究结果证实了 MSQ 在意大利语和一组需要接受药物戒断治疗的严重 CM 患者中的因子结构、信度和效度。
