Endocrine Cancer Group, Edinburgh Cancer Research UK Centre, MRC IGMM, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.
Br J Cancer. 2012 Jun 26;107(1):71-4. doi: 10.1038/bjc.2012.232. Epub 2012 May 29.
Duplication of the centromeric region of chromosome 17 (Ch17CEP) is associated with sensitivity to anthracyclines. An explanation may be chromosome instability (CIN); a frequent event in solid tumours associated with poor outcome. The predictive value of CIN seems to be drug dependent and CIN has been associated with both sensitivity and resistance to chemotherapy.
In this study, we used fluorescent in situ hybridisation for chromosomes 1, 7, 11, 17 and 18 to identify patients with high tumour CIN% in 322 patients recruited into the BR9601 clinical trial.
High tumour CIN% was correlated to Ch17CEP (P=3.68e-7) and is associated with a reduced RFS (P=0.0011) and OS (P=0.04). Patients with high CIN had a decreased risk of death on E-CMF compared with CMF.
CIN is of prognostic significance and may be of predictive value in determining anthracycline response, although further testing is required.
17 号染色体着丝粒区（Ch17CEP）的重复与蒽环类药物的敏感性相关。一种解释可能是染色体不稳定性（CIN）；这是一种在实体瘤中经常发生的事件，与不良预后相关。CIN 的预测价值似乎取决于药物，并且 CIN 与化疗的敏感性和耐药性都有关。
在这项研究中，我们使用荧光原位杂交技术来鉴定 322 名参加 BR9601 临床试验的患者中的高肿瘤 CIN%。
高肿瘤 CIN%与 Ch17CEP 相关（P=3.68e-7），并与降低的 RFS（P=0.0011）和 OS（P=0.04）相关。与 CMF 相比，高 CIN 的患者在 E-CMF 治疗中的死亡风险降低。
CIN 具有预后意义，并且可能对预测蒽环类药物反应具有价值，但需要进一步的测试。
