Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, BA11RL, England, UK.
Curr Rheumatol Rep. 2012 Aug;14(4):334-42. doi: 10.1007/s11926-012-0265-3.
Psoriatic arthritis is a distinct inflammatory arthritis associated with psoriasis and characterized by a broad clinical phenotype. Associated with skin disease, patients may have differing patterns of peripheral joint disease, spondyloarthritis, enthesitis, dactylitis, and nail disease with overlap and transition between phenotypes. Research over the past decade has resulted in a wealth of data to guide management, and several treatment algorithms have recently been published with varying emphasis on disease phenotype. This review discusses the incorporation of phenotype in the treatment of early disease, with extended discussion of current research and new concepts in disease measurement that will impact the development of future algorithms.
银屑病关节炎是一种与银屑病相关的独特炎症性关节炎，其特征为广泛的临床表型。与皮肤疾病相关，患者可能有不同模式的外周关节疾病、脊柱关节炎、附着点炎、指（趾）炎和甲病，各种表型之间存在重叠和转化。过去十年的研究产生了大量数据来指导治疗，最近发表了几种治疗算法，它们对疾病表型的重视程度不同。这篇综述讨论了在早期疾病治疗中纳入表型的问题，并对当前研究和疾病测量的新概念进行了扩展讨论，这些新概念将影响未来算法的发展。
