Department of Radiology, Shizuoka General Hospital, Kita-Ando 4-27-1, Shizuoka, Shizuoka, 420-8527, Japan.
Ann Nucl Med. 2012 Oct;26(8):684-7. doi: 10.1007/s12149-012-0612-5. Epub 2012 May 29.
A 70-year-old woman with a submucosal gastric tumor was referred to our hospital for surgical treatment. Upon examination, it was found that she had hypertension, and abdominal computed tomography revealed swelling on both adrenal glands. The patient was examined with gamma camera imaging and iodine-123 metaiodobenzylguanidine (MIBG), because her hypertension was thought to be due to a suspected adrenomedullary tumor. The planar image showed an unexpected abnormal uptake of MIBG in the upper abdomen. On single-photon emission computed tomographic images, the area of abnormal tracer uptake was thought to correspond to the known gastric tumor. The surgical procedure and histological assessments revealed that the gastric tumor was a gastrointestinal stromal tumor (GIST). MIBG can accumulate in GISTs as well as in neuroendocrine tumors of the medulla of the adrenal glands. Although the cause of radiolabeled MIBG uptake in GISTs is uncertain, further studies are necessary to establish the significance of MIBG scintigraphy in GIST imaging.
一位 70 岁的女性因胃黏膜下肿瘤被转诊至我院进行手术治疗。检查发现她患有高血压，腹部计算机断层扫描显示双侧肾上腺肿胀。对患者进行伽马相机成像和碘-123 间碘苄胍（MIBG）检查，因为她的高血压被认为是由于疑似肾上腺髓质肿瘤引起的。平面图像显示 MIBG 在腹部上异常摄取。在单光子发射计算机断层扫描图像上，异常示踪剂摄取的区域被认为与已知的胃部肿瘤相对应。手术过程和组织学评估显示胃部肿瘤为胃肠道间质瘤（GIST）。MIBG 可在 GIST 以及肾上腺髓质的神经内分泌肿瘤中积聚。尽管 GIST 中放射性标记 MIBG 摄取的原因尚不清楚，但需要进一步研究以确定 MIBG 闪烁显像在 GIST 成像中的意义。
