Bhanthumkomol Patommatat, Hijioka Susumu, Mizuno Nobumasa, Kuwahara Takamichi, Okuno Nozomi, Ito Ayako, Tanaka Tsutomu, Ishihara Makoto, Hirayama Yutaka, Onishi Sachiyo, Niwa Yasumasa, Tajika Masahiro, Ito Yuichi, Sasaki Eiichi, Inaba Yoshitaka, Shimizu Yasuhiro, Yatabe Yasushi, Hara Kazuo
Gastroenterology Unit, Thammasat University Hospital, Pathumthani, Thailand.
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan.
Clin J Gastroenterol. 2017 Aug;10(4):364-370. doi: 10.1007/s12328-017-0743-2. Epub 2017 Apr 26.
A 52-year-old woman was admitted with a large intraabdominal mass. I- metaiodobenzylguanidine (I-MIBG) scintigraphy revealed considerable I-MIBG accumulation by the mass that was compatible with a diagnosis of paraganglioma. However, a spindle cell tumor that was identified using endoscopic ultrasound-guided fine needle aspiration before surgery was positive for CD117. The surgically resected mass was confirmed as a gastrointestinal stromal tumor (GIST). Although the mechanism of I-MIBG uptake by GIST has not been elucidated, GIST should be included in the differential diagnosis of intra-abdominal tumor with I-MIBG uptake.
一名52岁女性因腹腔内巨大肿块入院。间碘苄胍（I-MIBG）闪烁扫描显示该肿块有大量I-MIBG聚集，符合副神经节瘤的诊断。然而，术前经内镜超声引导下细针穿刺活检确定的梭形细胞瘤CD117呈阳性。手术切除的肿块经证实为胃肠道间质瘤（GIST）。尽管GIST摄取I-MIBG的机制尚未阐明，但对于有I-MIBG摄取的腹腔内肿瘤，鉴别诊断时应考虑GIST。
