麻风病神经外膜的形态学变化：高分辨率超声检测到的新发现。
Morphological changes of the epineurium in leprosy: a new finding detected by high-resolution sonography.
机构信息
Department of Neurology and Clinical Neurophysiology, St Elisabeth hospital, Tilburg, The Netherlands.
出版信息
Muscle Nerve. 2012 Jul;46(1):38-41. doi: 10.1002/mus.23269. Epub 2012 May 29.
INTRODUCTION
From histopathological studies of peripheral nerves in leprosy, it is known that the epineurium can be thickened. We measured the epineurial thickness of the ulnar nerve by high resolution sonography (HRUS).
METHODS
The epineurium of the ulnar nerve was measured above the elbow on transverse scan in 25 healthy controls and 26 leprosy patients.
RESULTS
The mean epineurial thickness was 0.77 mm (95% confidence interval [CI] 0.66-0.88) in symptomatic ulnar nerves (n = 20), 0.58 mm (CI 0.51-0.65) in asymptomatic nerves (n = 30), and 0.49 mm (CI 0.44-0.54) in healthy controls (n = 25) (P = 0.0001). This thickening was related to the cross-sectional area of the ulnar nerve, but not with increased blood flow.
CONCLUSIONS
The epineurium of the ulnar nerve can be measured with the use of HRUS, and it is often strikingly thickened in leprosy patients, especially in those with ulnar involvement.
简介
从麻风病周围神经的组织病理学研究中可知，神经外膜可能会增厚。我们通过高分辨率超声（HRUS）测量了尺神经的神经外膜厚度。
方法
在 25 名健康对照者和 26 名麻风病患者的横断扫描中，我们测量了肘上尺神经的神经外膜。
结果
20 例症状性尺神经（n = 20）的平均神经外膜厚度为 0.77 毫米（95%置信区间[CI] 0.66-0.88），30 例无症状神经（n = 30）的厚度为 0.58 毫米（CI 0.51-0.65），25 名健康对照者（n = 25）的厚度为 0.49 毫米（CI 0.44-0.54）（P = 0.0001）。这种增厚与尺神经的横截面积有关，但与血流增加无关。
结论
HRUS 可用于测量尺神经的神经外膜，麻风病患者的神经外膜往往明显增厚，尤其是尺神经受累的患者。
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