Department of Neurology, Affiliated First Hospital, China Medical University, No. 155 Nanjingbei Road, Heping District, Shenyang 110001, People's Republic of China.
Acta Neurol Belg. 2012 Dec;112(4):367-74. doi: 10.1007/s13760-012-0090-5. Epub 2012 May 30.
Salicylate, the anti-inflammatory component of aspirin, induces transient tinnitus and hearing loss in clinical and animal experiments. However, the affected sites and mechanisms of generation remain unclear. Recently, down-regulation of inhibitory transmission mediated by γ-aminobutyric acid type A receptors was suggested to be crucial in generating tinnitus. However, the cell-specific pathways involved in this process were far from being understood. Here, we describe changes of inhibitory neurotransmitter, receptor, and glutamatergic axosomatic terminals in certain large GABAergic neurons (LGNs) in the inferior colliculus of rats treated with high doses of salicylate. Based on these results, we suggest that salicylate may affect inhibitory projection pathways from the inferior colliculus to the auditory cortex and lead to neural hyperactivity, perhaps by affecting the function of the LGNs.
水杨酸是阿司匹林中的抗炎成分，在临床和动物实验中会引起短暂的耳鸣和听力损失。然而，其产生的作用部位和机制尚不清楚。最近有研究表明，γ-氨基丁酸 A 型受体介导的抑制性传递的下调在耳鸣的产生中起着关键作用。然而，在此过程中涉及的细胞特异性途径仍远未被理解。在这里，我们描述了在高剂量水杨酸处理的大鼠的下丘脑中某些大 GABA 能神经元（LGNs）中抑制性神经递质、受体和谷氨酸能轴突末梢的变化。基于这些结果，我们认为水杨酸可能会影响从下丘侧向听觉皮层的抑制性投射通路，并导致神经活动过度，可能是通过影响 LGN 的功能。
