Department of Health Sciences, University of L'Aquila, L'Aquila, Italy.
J Cell Biochem. 2012 Nov;113(11):3342-52. doi: 10.1002/jcb.24210.
Gliobastoma (GB), the most common adult brain tumor, infiltrates normal brain area rendering impossible the complete surgical resection, resulting in a poor median survival (14-15 months), despite the aggressive multimodality treatments post-surgery, such as radiation and chemo-therapy. GB is characterized by hypoxic and necrotic regions due to a poorly organized tumor vascularization, leading to inadequate blood supply and consequently to hypoxic and necrotic areas. We have previously shown that, under hypoxia GB primary cells increased the expression of stemness markers as well as the expression of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) and also the crucial role played by PPARs in mouse neural stem cells maintenance and differentiation. Due to the importance of lipid signaling in cell proliferation and differentiation, in this work, we analyzed the expression of PPARs in GB neurospheres both in normoxic and hypoxic conditions. The results obtained suggest a differential regulation of the three PPARs by hypoxia, thus indicating a possible therapeutic strategy to counteract GB recurrencies.
胶质母细胞瘤（GB）是最常见的成人脑肿瘤，它浸润正常脑组织，使得完全手术切除成为不可能，导致中位生存时间（14-15 个月）较差，尽管术后采用了积极的多模态治疗，如放疗和化疗。由于肿瘤血管化组织不良，GB 组织缺氧和坏死区域，导致血液供应不足，进而导致缺氧和坏死区域。我们之前已经表明，在缺氧条件下，GB 原代细胞增加了干性标志物的表达，以及核受体过氧化物酶体增殖物激活受体α（PPARα）的表达，并且 PPARs 在维持和分化小鼠神经干细胞中的关键作用。由于脂质信号在细胞增殖和分化中的重要性，在这项工作中，我们分析了在常氧和缺氧条件下 GB 神经球中 PPARs 的表达。结果表明，缺氧对三种 PPARs 进行了差异调节，因此表明了一种可能的治疗策略来对抗 GB 的复发。
